L22P (p.Leu22Pro) variant of APOB (Apolipoprotein B-100)
L22P (p.Leu22Pro) in APOB (Apolipoprotein B-100) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
L22P (p.Leu22Pro) variant details
- p.Leu22Pro
- Ensembl rs972976755
- Missense
- Variant Prioritization Score for Impact Estimate 0.306
- REVEL 0.09
- MetaLR 0.01
- MetaSVM -0.97
- CADD 17.00
- PolyPhen-2 0.01
- SIFT 0.21
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available