L131V (p.Leu131Val) variant of APOB (Apolipoprotein B-100)
L131V (p.Leu131Val) in APOB (Apolipoprotein B-100) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
L131V (p.Leu131Val) variant details
- p.Leu131Val
- ExAC rs766149422
- gnomAD rs766149422
- Missense
- Variant Prioritization Score for Impact Estimate 0.35
- REVEL 0.14
- MetaLR 0.18
- MetaSVM -0.85
- CADD 25.70
- PolyPhen-2 1.00
- SIFT 0.08
- Most common in the 1KG:IBS population (allele frequency 0.017)
- Structural context available