L16L (p.Leu16Leu) variant of APC (Adenomatous polyposis coli protein)
L16L (p.Leu16Leu) in APC (Adenomatous polyposis coli protein) is a synonymous change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data, published literature, and structural context.
L16L (p.Leu16Leu) variant details
- p.Leu16Leu
- rs1057520603
- gnomAD 5-112754936-C-T
- Synonymous
- Variant Prioritization Score for Impact Estimate 0.523
- AlphaMissense 0.96
- MetaLR 0.12
- MetaSVM -0.99
- CADD 10.70
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the 1KG:FIN population (allele frequency 0.0051)
- Structural context available
- Literature evidence available