A4G (p.Ala4Gly) variant of APC (Adenomatous polyposis coli protein)
A4G (p.Ala4Gly) in APC (Adenomatous polyposis coli protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
A4G (p.Ala4Gly) variant details
- p.Ala4Gly
- Ensembl rs2149737293
- Missense
- Variant Prioritization Score for Impact Estimate 0.353
- REVEL 0.17
- ESM-1b 0.00
- AlphaMissense 0.43
- MetaLR 0.09
- MetaSVM -1.08
- CADD 25.20
- Most common in the Latino/Admixed American population (allele frequency 0.00011)
- Structural context available