A3P (p.Ala3Pro) variant of APC (Adenomatous polyposis coli protein)
A3P (p.Ala3Pro) in APC (Adenomatous polyposis coli protein) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes structural context.
A3P (p.Ala3Pro) variant details
- p.Ala3Pro
- Ensembl rs2149737242
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.268
- REVEL 0.30
- ESM-1b 0.00
- AlphaMissense 0.60
- MetaLR 0.12
- MetaSVM -0.95
- SIFT 0.02
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available