P32Q (p.Pro32Gln) variant of ALK (ALK tyrosine kinase receptor)
P32Q (p.Pro32Gln) in ALK (ALK tyrosine kinase receptor) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
P32Q (p.Pro32Gln) variant details
- p.Pro32Gln
- ExAC rs759748510
- TOPMed rs759748510
- gnomAD rs759748510
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.114
- REVEL 0.04
- MetaLR 0.24
- MetaSVM -0.95
- CADD 9.51
- PolyPhen-2 0.00
- SIFT 0.21
- EBI: Likely benign
- UniProt: Likely benign
- Population evidence available
- Structural context available