W73C (p.Trp73Cys) variant of ADCY5 (Adenylate cyclase type 5)
W73C (p.Trp73Cys) in ADCY5 (Adenylate cyclase type 5) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.52 / 1. The record also includes population frequency data and structural context.
W73C (p.Trp73Cys) variant details
- p.Trp73Cys
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.521
- REVEL 0.48
- MetaLR 0.43
- MetaSVM -0.06
- CADD 25.20
- PolyPhen-2 0.71
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available