S4Y (p.Ser4Tyr) variant of ADCY5 (Adenylate cyclase type 5)
S4Y (p.Ser4Tyr) in ADCY5 (Adenylate cyclase type 5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
S4Y (p.Ser4Tyr) variant details
- p.Ser4Tyr
- TOPMed rs1945873673
- gnomAD rs1945873673
- Missense
- Variant Prioritization Score for Impact Estimate 0.513
- REVEL 0.40
- MetaLR 0.41
- MetaSVM -0.05
- CADD 26.60
- PolyPhen-2 0.50
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 4.3e-05)
- Structural context available