P63A (p.Pro63Ala) variant of ADCY5 (Adenylate cyclase type 5)
P63A (p.Pro63Ala) in ADCY5 (Adenylate cyclase type 5) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
P63A (p.Pro63Ala) variant details
- p.Pro63Ala
- ExAC rs759057691
- gnomAD rs759057691
- Missense
- Variant Prioritization Score for Impact Estimate 0.447
- REVEL 0.28
- MetaLR 0.33
- MetaSVM -0.49
- CADD 24.80
- PolyPhen-2 0.96
- SIFT 0.06
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available