G85S (p.Gly85Ser) variant of ADCY5 (Adenylate cyclase type 5)
G85S (p.Gly85Ser) in ADCY5 (Adenylate cyclase type 5) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
G85S (p.Gly85Ser) variant details
- p.Gly85Ser
- ExAC rs764919392
- TOPMed rs764919392
- gnomAD rs764919392
- Uncertain significance
- Missense
- Variant Prioritization Score for Impact Estimate 0.302
- REVEL 0.19
- MetaLR 0.19
- MetaSVM -0.89
- CADD 16.00
- PolyPhen-2 0.00
- SIFT 0.08
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available