Warfarin sensitivity, X-linked: genes and variants
Warfarin sensitivity, X-linked is linked to 1 analyzed protein (F9). 6 DNA variants are known to cause it; 0 more are uncertain, and 0 of those already look disease-causing on computable evidence.
Last updated 2026-09-30. Research information, not medical advice.
Genes linked to Warfarin sensitivity, X-linked
F9: Coagulation factor IX
Its activated form combines with factor VIIIa to efficiently activate factor X during coagulation. Pathogenic loss-of-function variants cause X-linked hemophilia B, with bleeding severity determined largely by residual factor IX activity.
6 disease-causing and 0 uncertain variants in F9 are linked to Warfarin sensitivity, X-linked.
Known disease-causing variants in Warfarin sensitivity, X-linked
| Variant | Position | Protein part | Clinical label |
|---|---|---|---|
| F9 R191C | 191 | Disease-causing (★★★★) | |
| F9 I443T | 443 | Peptidase S1 | Disease-causing (★★) |
| F9 F55I | 55 | Gla | Disease-causing (★★) |
| F9 T342A | 342 | Peptidase S1 | Disease-causing (★★) |
| F9 N392D | 392 | Peptidase S1 | Disease-causing (★★) |
| F9 A37V | 37 | Disease-causing |
Same protein, different disease
- Hereditary factor IX deficiency disease is also caused by F9 variants; they fall mostly in different places as the Warfarin sensitivity, X-linked variants (157 disease-causing).
- Thrombophilia, X-linked, due to factor 9 defect is also caused by F9 variants; they fall mostly in different places as the Warfarin sensitivity, X-linked variants (62 disease-causing).
Diseases related to Warfarin sensitivity, X-linked
- Hereditary factor VIII deficiency disease, also linked to F9
- Hereditary factor IX deficiency disease, also linked to F9
- Thrombophilia, X-linked, due to factor 9 defect, also linked to F9
Frequently asked questions
Which genes are linked to Warfarin sensitivity, X-linked?
In CATVariant, Warfarin sensitivity, X-linked is linked to 1 analyzed protein: F9 (Coagulation factor IX).
How many genetic variants are linked to Warfarin sensitivity, X-linked?
8 variants: 6 are classified as disease-causing (pathogenic or likely pathogenic) in ClinVar and 0 are of uncertain significance or have conflicting reports.
Which uncertain variants in Warfarin sensitivity, X-linked look disease-causing?
None of the uncertain variants currently reaches the likely-pathogenic range on computable evidence alone.
About this data
Variant–disease links come from ClinVar, Open Targets and UniProt, pooled from the latest public CATVariant analysis of each human protein. Evidence scores use the ACMG/AMP Bayesian points scale with computable criteria only (position among known disease variants, rarity in gnomAD, calibrated predictors, deep mutational scanning); there is no family or patient data, so they prioritise variants for expert review and never classify them.
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