Susceptibility to respiratory infections associated with CD8alpha chain mutation: genes and variants
Susceptibility to respiratory infections associated with CD8alpha chain mutation is linked to 1 analyzed protein (CD8A). 1 DNA variants are known to cause it; 71 more are uncertain, and 0 of those already look disease-causing on computable evidence.
Last updated 2026-09-30. Research information, not medical advice.
Genes linked to Susceptibility to respiratory infections associated with CD8alpha chain mutation
CD8A: T-cell surface glycoprotein CD8 alpha chain
It helps cytotoxic T cells recognize peptide-loaded MHC class I molecules and strengthens T-cell receptor signaling during immune surveillance. Deficiency can impair cytotoxic T-cell responses, while CD8 expression is widely used to identify and characterize cytotoxic lymphocytes.
1 disease-causing and 71 uncertain variants in CD8A are linked to Susceptibility to respiratory infections associated with CD8alpha chain mutation.
Known disease-causing variants in Susceptibility to respiratory infections associated with CD8alpha chain mutation
| Variant | Position | Protein part | Clinical label |
|---|---|---|---|
| CD8A G111S | 111 | Ig-like V-type | Disease-causing (★) |
Frequently asked questions
Which genes are linked to Susceptibility to respiratory infections associated with CD8alpha chain mutation?
In CATVariant, Susceptibility to respiratory infections associated with CD8alpha chain mutation is linked to 1 analyzed protein: CD8A (T-cell surface glycoprotein CD8 alpha chain).
How many genetic variants are linked to Susceptibility to respiratory infections associated with CD8alpha chain mutation?
74 variants: 1 are classified as disease-causing (pathogenic or likely pathogenic) in ClinVar and 71 are of uncertain significance or have conflicting reports.
Which uncertain variants in Susceptibility to respiratory infections associated with CD8alpha chain mutation look disease-causing?
None of the uncertain variants currently reaches the likely-pathogenic range on computable evidence alone.
About this data
Variant–disease links come from ClinVar, Open Targets and UniProt, pooled from the latest public CATVariant analysis of each human protein. Evidence scores use the ACMG/AMP Bayesian points scale with computable criteria only (position among known disease variants, rarity in gnomAD, calibrated predictors, deep mutational scanning); there is no family or patient data, so they prioritise variants for expert review and never classify them.
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