RAD51C-related cancer predisposition: genes and variants
RAD51C-related cancer predisposition is linked to 1 analyzed protein (RAD51C). 2 DNA variants are known to cause it; 0 more are uncertain, and 0 of those already look disease-causing on computable evidence.
Last updated 2026-09-30. Research information, not medical advice.
Genes linked to RAD51C-related cancer predisposition
RAD51C: DNA repair protein RAD51 homolog 3
It participates in RAD51-paralog complexes that promote homologous-recombination repair and restart damaged replication forks. Heterozygous loss-of-function variants increase ovarian and breast-cancer risk, while biallelic variants can cause Fanconi anemia.
2 disease-causing and 0 uncertain variants in RAD51C are linked to RAD51C-related cancer predisposition.
Known disease-causing variants in RAD51C-related cancer predisposition
| Variant | Position | Protein part | Clinical label |
|---|---|---|---|
| RAD51C L138F | 138 | Disease-causing (★★) | |
| RAD51C R258H | 258 | Disease-causing (★★) |
Same protein, different disease
- Breast-ovarian cancer, familial, susceptibility to, 1 is also caused by RAD51C variants; they fall mostly in different places as the RAD51C-related cancer predisposition variants (9 disease-causing).
- Fanconi anemia complementation group O is also caused by RAD51C variants; they fall mostly in different places as the RAD51C-related cancer predisposition variants (4 disease-causing).
- Hereditary breast ovarian cancer syndrome is also caused by RAD51C variants; they fall mostly in different places as the RAD51C-related cancer predisposition variants (3 disease-causing).
Diseases related to RAD51C-related cancer predisposition
- Ovarian cancer, also linked to RAD51C
- Fanconi anemia, also linked to RAD51C
- Gastric cancer, also linked to RAD51C
- Breast-ovarian cancer, familial, susceptibility to, 1, also linked to RAD51C
- Hereditary breast ovarian cancer syndrome, also linked to RAD51C
- Breast and/or ovarian cancer, also linked to RAD51C
- Familial ovarian cancer, also linked to RAD51C
- Fanconi anemia complementation group O, also linked to RAD51C
Frequently asked questions
Which genes are linked to RAD51C-related cancer predisposition?
In CATVariant, RAD51C-related cancer predisposition is linked to 1 analyzed protein: RAD51C (DNA repair protein RAD51 homolog 3).
How many genetic variants are linked to RAD51C-related cancer predisposition?
6 variants: 2 are classified as disease-causing (pathogenic or likely pathogenic) in ClinVar and 0 are of uncertain significance or have conflicting reports.
Which uncertain variants in RAD51C-related cancer predisposition look disease-causing?
None of the uncertain variants currently reaches the likely-pathogenic range on computable evidence alone.
About this data
Variant–disease links come from ClinVar, Open Targets and UniProt, pooled from the latest public CATVariant analysis of each human protein. Evidence scores use the ACMG/AMP Bayesian points scale with computable criteria only (position among known disease variants, rarity in gnomAD, calibrated predictors, deep mutational scanning); there is no family or patient data, so they prioritise variants for expert review and never classify them.
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