S21W (p.Ser21Trp) variant of YAP1 (Transcriptional coactivator YAP1)
S21W (p.Ser21Trp) in YAP1 (Transcriptional coactivator YAP1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
S21W (p.Ser21Trp) variant details
- p.Ser21Trp
- gnomAD 11-102110910-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.249
- REVEL 0.08
- CADD 22.50
- PolyPhen-2 0.07
- SIFT 0.00
- Most common in the Middle Eastern population (allele frequency 0.00027)
- Structural context available
- YAP1 WW domain domainome 1.0: score -0.621
- Literature evidence available