P24L (p.Pro24Leu) variant of YAP1 (Transcriptional coactivator YAP1)
P24L (p.Pro24Leu) in YAP1 (Transcriptional coactivator YAP1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P24L (p.Pro24Leu) variant details
- p.Pro24Leu
- TOPMed rs1395090279
- gnomAD rs1395090279
- Missense
- Variant Prioritization Score for Impact Estimate 0.198
- REVEL 0.06
- CADD 18.20
- PolyPhen-2 0.00
- SIFT 0.09
- Most common in the African/African-American population (allele frequency 4.8e-05)
- Structural context available
- YAP1 WW domain domainome 1.0: score -0.813