P23S (p.Pro23Ser) variant of YAP1 (Transcriptional coactivator YAP1)
P23S (p.Pro23Ser) in YAP1 (Transcriptional coactivator YAP1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.13 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P23S (p.Pro23Ser) variant details
- p.Pro23Ser
- TOPMed rs1465441942
- gnomAD rs1465441942
- Missense
- Variant Prioritization Score for Impact Estimate 0.134
- REVEL 0.03
- CADD 12.90
- PolyPhen-2 0.01
- SIFT 0.31
- Most common in the South Asian population (allele frequency 4.6e-05)
- Structural context available
- YAP1 WW domain domainome 1.0: score -0.877