P23A (p.Pro23Ala) variant of YAP1 (Transcriptional coactivator YAP1)
P23A (p.Pro23Ala) in YAP1 (Transcriptional coactivator YAP1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.12 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P23A (p.Pro23Ala) variant details
- p.Pro23Ala
- TOPMed rs1465441942
- gnomAD rs1465441942
- Missense
- Variant Prioritization Score for Impact Estimate 0.125
- REVEL 0.03
- CADD 10.70
- PolyPhen-2 0.00
- SIFT 0.33
- Most common in the African/African-American population (allele frequency 7.3e-05)
- Structural context available
- YAP1 WW domain domainome 1.0: score -0.877