P20L (p.Pro20Leu) variant of YAP1 (Transcriptional coactivator YAP1)
P20L (p.Pro20Leu) in YAP1 (Transcriptional coactivator YAP1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P20L (p.Pro20Leu) variant details
- p.Pro20Leu
- TOPMed rs1942853316
- Missense
- Variant Prioritization Score for Impact Estimate 0.171
- REVEL 0.05
- CADD 17.50
- PolyPhen-2 0.00
- SIFT 0.17
- Most common in the HGDP:PALESTINIAN population (allele frequency 0.013)
- Structural context available
- YAP1 WW domain domainome 1.0: score -0.44