P11L (p.Pro11Leu) variant of YAP1 (Transcriptional coactivator YAP1)
P11L (p.Pro11Leu) in YAP1 (Transcriptional coactivator YAP1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data, experimental measurements, and structural context.
P11L (p.Pro11Leu) variant details
- p.Pro11Leu
- 1000Genomes rs2135084131
- Missense
- Variant Prioritization Score for Impact Estimate 0.191
- REVEL 0.03
- CADD 22.50
- PolyPhen-2 0.02
- SIFT 0.00
- Most common in the 1KG:PUR population (allele frequency 0.0051)
- Structural context available
- YAP1 WW domain domainome 1.0: score -0.497