G15D (p.Gly15Asp) variant of YAP1 (Transcriptional coactivator YAP1)
G15D (p.Gly15Asp) in YAP1 (Transcriptional coactivator YAP1) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data, experimental measurements, and structural context.
G15D (p.Gly15Asp) variant details
- p.Gly15Asp
- ExAC rs762152510
- TOPMed rs762152510
- gnomAD rs762152510
- Missense
- Variant Prioritization Score for Impact Estimate 0.216
- REVEL 0.05
- CADD 22.90
- PolyPhen-2 0.02
- SIFT 0.03
- Most common in the South Asian population (allele frequency 0.00021)
- Structural context available
- YAP1 WW domain domainome 1.0: score -0.616