D2Y (p.Asp2Tyr) variant of YAP1 (Transcriptional coactivator YAP1)
D2Y (p.Asp2Tyr) in YAP1 (Transcriptional coactivator YAP1) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, experimental measurements, and structural context.
D2Y (p.Asp2Tyr) variant details
- p.Asp2Tyr
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.215
- REVEL 0.03
- CADD 22.90
- PolyPhen-2 0.04
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available
- YAP1 WW domain domainome 1.0: score -0.346