T77M (p.Thr77Met) variant of XRCC3 (DNA repair protein XRCC3)
T77M (p.Thr77Met) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.11 / 1. The record also includes population frequency data and structural context.
T77M (p.Thr77Met) variant details
- p.Thr77Met
- TOPMed rs1003077931
- gnomAD rs1003077931
- Missense
- Variant Prioritization Score for Impact Estimate 0.112
- REVEL 0.05
- AlphaMissense 0.08
- MetaLR 0.07
- MetaSVM -1.04
- CADD 3.01
- PolyPhen-2 0.90
- Most common in the Middle Eastern population (allele frequency 0.00041)
- Structural context available