S110L (p.Ser110Leu) variant of XRCC3 (DNA repair protein XRCC3)
S110L (p.Ser110Leu) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data and structural context.
S110L (p.Ser110Leu) variant details
- p.Ser110Leu
- ExAC rs577087507
- TOPMed rs577087507
- gnomAD rs577087507
- Missense
- Variant Prioritization Score for Impact Estimate 0.556
- REVEL 0.48
- CADD 24.80
- PolyPhen-2 0.96
- SIFT 0.04
- Most common in the South Asian population (allele frequency 3.8e-05)
- Structural context available