R94C (p.Arg94Cys) variant of XRCC3 (DNA repair protein XRCC3)
R94C (p.Arg94Cys) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
R94C (p.Arg94Cys) variant details
- p.Arg94Cys
- TOPMed rs1317589130
- gnomAD rs1317589130
- Missense
- Variant Prioritization Score for Impact Estimate 0.243
- REVEL 0.14
- CADD 19.20
- PolyPhen-2 0.95
- SIFT 0.04
- Most common in the African/African-American population (allele frequency 3.2e-05)
- Structural context available