R81C (p.Arg81Cys) variant of XRCC3 (DNA repair protein XRCC3)
R81C (p.Arg81Cys) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data and structural context.
R81C (p.Arg81Cys) variant details
- p.Arg81Cys
- cosmic curated COSV10742
- TOPMed rs1297812518
- gnomAD rs1297812518
- Missense
- Variant Prioritization Score for Impact Estimate 0.575
- REVEL 0.42
- CADD 28.60
- PolyPhen-2 0.97
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available