R58W (p.Arg58Trp) variant of XRCC3 (DNA repair protein XRCC3)
R58W (p.Arg58Trp) in XRCC3 (DNA repair protein XRCC3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
R58W (p.Arg58Trp) variant details
- p.Arg58Trp
- rs143410843
- cosmic curated COSV10072
- ESP rs143410843
- ExAC rs143410843
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.437
- REVEL 0.36
- CADD 23.80
- PolyPhen-2 0.91
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 8.8e-05)
- Structural context available