R11T (p.Arg11Thr) variant of XRCC3 (DNA repair protein XRCC3)
R11T (p.Arg11Thr) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
R11T (p.Arg11Thr) variant details
- p.Arg11Thr
- TOPMed rs1474638790
- gnomAD rs1474638790
- Missense
- Variant Prioritization Score for Impact Estimate 0.443
- REVEL 0.21
- CADD 24.90
- PolyPhen-2 0.70
- SIFT 0.05
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available