R108C (p.Arg108Cys) variant of XRCC3 (DNA repair protein XRCC3)
R108C (p.Arg108Cys) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.09 / 1. The record also includes population frequency data and structural context.
R108C (p.Arg108Cys) variant details
- p.Arg108Cys
- cosmic curated COSV61398
- TOPMed rs934186909
- gnomAD rs934186909
- Missense
- Variant Prioritization Score for Impact Estimate 0.0926
- REVEL 0.07
- CADD 9.44
- PolyPhen-2 0.01
- SIFT 0.07
- Most common in the REMAINING population (allele frequency 5.2e-05)
- Structural context available