P98L (p.Pro98Leu) variant of XRCC3 (DNA repair protein XRCC3)
P98L (p.Pro98Leu) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data and structural context.
P98L (p.Pro98Leu) variant details
- p.Pro98Leu
- TOPMed rs1454280648
- gnomAD rs1454280648
- Missense
- Variant Prioritization Score for Impact Estimate 0.473
- REVEL 0.29
- CADD 21.90
- PolyPhen-2 0.31
- SIFT 0.17
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available