P87L (p.Pro87Leu) variant of XRCC3 (DNA repair protein XRCC3)
P87L (p.Pro87Leu) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.40 / 1. The record also includes population frequency data and structural context.
P87L (p.Pro87Leu) variant details
- p.Pro87Leu
- ExAC rs749386482
- TOPMed rs749386482
- gnomAD rs749386482
- Missense
- Variant Prioritization Score for Impact Estimate 0.395
- REVEL 0.29
- CADD 25.30
- PolyPhen-2 0.90
- SIFT 0.00
- Most common in the Middle Eastern population (allele frequency 0.00097)
- Structural context available