P76L (p.Pro76Leu) variant of XRCC3 (DNA repair protein XRCC3)
P76L (p.Pro76Leu) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data and structural context.
P76L (p.Pro76Leu) variant details
- p.Pro76Leu
- TOPMed rs940858162
- gnomAD rs940858162
- Missense
- Variant Prioritization Score for Impact Estimate 0.408
- REVEL 0.20
- CADD 19.60
- PolyPhen-2 0.03
- SIFT 0.23
- Most common in the African/African-American population (allele frequency 7.2e-05)
- Structural context available