P127L (p.Pro127Leu) variant of XRCC3 (DNA repair protein XRCC3)
P127L (p.Pro127Leu) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
P127L (p.Pro127Leu) variant details
- p.Pro127Leu
- TOPMed rs1169944170
- gnomAD rs1169944170
- Missense
- Variant Prioritization Score for Impact Estimate 0.612
- REVEL 0.57
- CADD 26.70
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 3.1e-05)
- Structural context available