L99P (p.Leu99Pro) variant of XRCC3 (DNA repair protein XRCC3)
L99P (p.Leu99Pro) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data and structural context.
L99P (p.Leu99Pro) variant details
- p.Leu99Pro
- gnomAD rs1156340369
- Missense
- Variant Prioritization Score for Impact Estimate 0.318
- REVEL 0.19
- CADD 22.90
- PolyPhen-2 0.22
- SIFT 0.02
- Most common in the Latino/Admixed American population (allele frequency 5.6e-05)
- Structural context available