L8M (p.Leu8Met) variant of XRCC3 (DNA repair protein XRCC3)
L8M (p.Leu8Met) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data and structural context.
L8M (p.Leu8Met) variant details
- p.Leu8Met
- TOPMed rs1158944601
- Missense
- Variant Prioritization Score for Impact Estimate 0.384
- REVEL 0.24
- CADD 24.30
- PolyPhen-2 0.92
- SIFT 0.04
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available