L89P (p.Leu89Pro) variant of XRCC3 (DNA repair protein XRCC3)
L89P (p.Leu89Pro) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.73 / 1. The record also includes population frequency data and structural context.
L89P (p.Leu89Pro) variant details
- p.Leu89Pro
- TOPMed rs1486474805
- gnomAD rs1486474805
- Missense
- Variant Prioritization Score for Impact Estimate 0.726
- REVEL 0.80
- CADD 25.50
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the South Asian population (allele frequency 1.3e-05)
- Structural context available