L35S (p.Leu35Ser) variant of XRCC3 (DNA repair protein XRCC3)
L35S (p.Leu35Ser) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data and structural context.
L35S (p.Leu35Ser) variant details
- p.Leu35Ser
- gnomAD rs1285485875
- Missense
- Variant Prioritization Score for Impact Estimate 0.643
- REVEL 0.65
- CADD 25.30
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available