L21M (p.Leu21Met) variant of XRCC3 (DNA repair protein XRCC3)
L21M (p.Leu21Met) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
L21M (p.Leu21Met) variant details
- p.Leu21Met
- gnomAD rs1595670725
- Missense
- Variant Prioritization Score for Impact Estimate 0.464
- REVEL 0.20
- CADD 22.60
- PolyPhen-2 0.95
- SIFT 0.00
- Most common in the REMAINING population (allele frequency 0.00048)
- Structural context available