L120P (p.Leu120Pro) variant of XRCC3 (DNA repair protein XRCC3)
L120P (p.Leu120Pro) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.70 / 1. The record also includes population frequency data and structural context.
L120P (p.Leu120Pro) variant details
- p.Leu120Pro
- TOPMed rs1283768515
- gnomAD rs1283768515
- Missense
- Variant Prioritization Score for Impact Estimate 0.698
- REVEL 0.73
- CADD 29.10
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 7.2e-05)
- Structural context available