L118P (p.Leu118Pro) variant of XRCC3 (DNA repair protein XRCC3)
L118P (p.Leu118Pro) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes population frequency data and structural context.
L118P (p.Leu118Pro) variant details
- p.Leu118Pro
- 1000Genomes rs749582836
- ExAC rs749582836
- TOPMed rs749582836
- gnomAD rs749582836
- Missense
- Variant Prioritization Score for Impact Estimate 0.592
- REVEL 0.55
- CADD 28.50
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the 1KG:STU population (allele frequency 0.0051)
- Structural context available