K17N (p.Lys17Asn) variant of XRCC3 (DNA repair protein XRCC3)
K17N (p.Lys17Asn) in XRCC3 (DNA repair protein XRCC3) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
K17N (p.Lys17Asn) variant details
- p.Lys17Asn
- rs770709968
- NCI-TCGA Cosmic COSV9938
- cosmic curated COSV99386
- ExAC rs770709968
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.222
- REVEL 0.10
- CADD 23.90
- PolyPhen-2 0.54
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available