I140V (p.Ile140Val) variant of XRCC3 (DNA repair protein XRCC3)
I140V (p.Ile140Val) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.10 / 1. The record also includes population frequency data and structural context.
I140V (p.Ile140Val) variant details
- p.Ile140Val
- TOPMed rs1254281866
- gnomAD rs1254281866
- Missense
- Variant Prioritization Score for Impact Estimate 0.097
- REVEL 0.07
- CADD 10.10
- PolyPhen-2 0.12
- SIFT 0.35
- Most common in the South Asian population (allele frequency 3.8e-05)
- Structural context available