G95S (p.Gly95Ser) variant of XRCC3 (DNA repair protein XRCC3)
G95S (p.Gly95Ser) in XRCC3 (DNA repair protein XRCC3) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.78 / 1. The record also includes population frequency data and structural context.
G95S (p.Gly95Ser) variant details
- p.Gly95Ser
- cosmic curated COSV61398
- TOPMed rs1024591176
- gnomAD rs1024591176
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.775
- REVEL 0.79
- CADD 23.80
- PolyPhen-2 1.00
- SIFT 0.00
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the East Asian population (allele frequency 5.6e-05)
- Structural context available