C121Y (p.Cys121Tyr) variant of XRCC3 (DNA repair protein XRCC3)
C121Y (p.Cys121Tyr) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data and structural context.
C121Y (p.Cys121Tyr) variant details
- p.Cys121Tyr
- ExAC rs769958215
- TOPMed rs769958215
- gnomAD rs769958215
- Missense
- Variant Prioritization Score for Impact Estimate 0.541
- REVEL 0.45
- CADD 25.20
- PolyPhen-2 0.98
- SIFT 0.00
- Most common in the East Asian population (allele frequency 0.00019)
- Structural context available