C121S (p.Cys121Ser) variant of XRCC3 (DNA repair protein XRCC3)
C121S (p.Cys121Ser) in XRCC3 (DNA repair protein XRCC3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.36 / 1. The record also includes population frequency data and structural context.
C121S (p.Cys121Ser) variant details
- p.Cys121Ser
- ExAC rs769958215
- TOPMed rs769958215
- gnomAD rs769958215
- Missense
- Variant Prioritization Score for Impact Estimate 0.363
- REVEL 0.18
- CADD 21.60
- PolyPhen-2 0.10
- SIFT 0.18
- Most common in the South Asian population (allele frequency 3.7e-05)
- Structural context available