Y59H (p.Tyr59His) variant of XRCC2 (DNA repair protein XRCC2)
Y59H (p.Tyr59His) in XRCC2 (DNA repair protein XRCC2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data, published literature, and structural context.
Y59H (p.Tyr59His) variant details
- p.Tyr59His
- gnomAD 7-152649310-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.411
- REVEL 0.31
- MetaLR 0.09
- MetaSVM -1.07
- CADD 26.90
- PolyPhen-2 0.96
- SIFT 0.00
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available
- Literature evidence available