T12S (p.Thr12Ser) variant of XRCC2 (DNA repair protein XRCC2)
T12S (p.Thr12Ser) in XRCC2 (DNA repair protein XRCC2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, published literature, and structural context.
T12S (p.Thr12Ser) variant details
- p.Thr12Ser
- gnomAD 7-152676045-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.316
- REVEL 0.08
- MetaLR 0.11
- MetaSVM -0.94
- CADD 22.60
- PolyPhen-2 0.00
- SIFT 0.05
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available