L15F (p.Leu15Phe) variant of XRCC2 (DNA repair protein XRCC2)
L15F (p.Leu15Phe) in XRCC2 (DNA repair protein XRCC2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, published literature, and structural context.
L15F (p.Leu15Phe) variant details
- p.Leu15Phe
- gnomAD 7-152660779-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.283
- REVEL 0.04
- MetaLR 0.17
- MetaSVM -0.88
- CADD 22.00
- PolyPhen-2 0.35
- SIFT 0.50
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available