L14I (p.Leu14Ile) variant of XRCC2 (DNA repair protein XRCC2)
L14I (p.Leu14Ile) in XRCC2 (DNA repair protein XRCC2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact in the context of in SPGF50 and POF17. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
L14I (p.Leu14Ile) variant details
- p.Leu14Ile
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- in SPGF50 and POF17
- Missense
- Variant Prioritization Score for Impact Estimate 0.371
- REVEL 0.16
- MetaLR 0.39
- MetaSVM -0.36
- CADD 26.70
- PolyPhen-2 0.84
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact. (in SPGF50 and POF17)
- Population evidence available
- Structural context available