E35G (p.Glu35Gly) variant of XRCC2 (DNA repair protein XRCC2)
E35G (p.Glu35Gly) in XRCC2 (DNA repair protein XRCC2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, published literature, and structural context.
E35G (p.Glu35Gly) variant details
- p.Glu35Gly
- gnomAD 7-152660718-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.319
- REVEL 0.14
- MetaLR 0.16
- MetaSVM -0.92
- CADD 23.30
- PolyPhen-2 0.20
- SIFT 0.07
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available