F27L (p.Phe27Leu) variant of XIAP (E3 ubiquitin-protein ligase XIAP)
F27L (p.Phe27Leu) in XIAP (E3 ubiquitin-protein ligase XIAP) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
F27L (p.Phe27Leu) variant details
- p.Phe27Leu
- ExAC rs745585920
- gnomAD rs745585920
- Missense
- Variant Prioritization Score for Impact Estimate 0.136
- REVEL 0.06
- CADD 12.60
- PolyPhen-2 0.00
- SIFT 0.85
- Most common in the Non-Finnish European population (allele frequency 1.2e-06)
- Structural context available